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Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.

Author:
  • Jonathan Esguerra
  • Caroline Bolmeson
  • Corrado Cilio
  • Lena Eliasson
Publishing year: 2011
Language: English
Publication/Series: PLoS ONE
Volume: 6
Issue: 4
Document type: Journal article
Publisher: Public Library of Science

Abstract english

The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.

Keywords

  • Endocrinology and Diabetes
  • Islets of Langerhans/*drug effects/*metabolism
  • MicroRNAs/*genetics
  • Glucose/*pharmacology
  • Gene Expression Profiling
  • Animals
  • Type 2/*metabolism
  • Diabetes Mellitus
  • Polymerase Chain Reaction
  • Rats
  • Wistar

Other

Published
  • Islet cell exocytosis
  • Cellular Autoimmunity
  • ISSN: 1932-6203
Caroline Bolmeson
E-mail: caroline [dot] bolmeson [at] biol [dot] lu [dot] se

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