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Novel combined fluorescence/reflectance spectroscopy system for guiding brain tumor resections - hardware considerations

  • Zhiyuan Xie
  • Haiyan Xie
  • Monirehalsadat Mousavi
  • Mikkel Brydegaard
  • Johan Axelsson
  • Stefan Andersson-Engels
Publishing year: 2013
Language: English
Pages: 90320-90320
Publication/Series: Biophotonics—Riga 2013 (Proceedings of SPIE)
Volume: 9032
Document type: Conference paper
Publisher: SPIE

Abstract english

Glioblastoma multiforme (GBM) has long been known as the most common and aggressive form of brain malignancy. The morphological similarities of the malignant and surrounding tissue cause difficulties to distinct the tumors during surgery. In order to achieve better results in resecting malignant brain tumors, a fiber based optical system which can be used intraoperative is developed in this project. In this context, the system hardware details, system controlling interfaces and laboratory testing results are presented. Based on the results obtained from various tests with tissue-equivalent phantoms, the system is proved to have stable performance, robust structure, and have good linearity as well as high sensitivity to low PpIX concentration under strong ambient light conditions.


  • Atom and Molecular Physics and Optics
  • Glioblastoma multiforme (GBM)
  • tumor resection
  • PpIX fluorescence
  • fiber
  • optical probe
  • ambient light rejection


1st International Conference on Biophotonics-Riga
  • ISSN: 1996-756X
  • ISSN: 0277-786X
Mikkel Brygdegaard
E-mail: mikkel [dot] brydegaard [at] forbrf [dot] lth [dot] se

Associate senior lecturer

Combustion Physics

+46 46 222 76 57



Centre for Animal Movement Research
Evolutionary Ecology, Department of Biology
Ecology building S-223 62 Lund Sweden