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Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections _ Confirmation of capability in lab experiments

  • Monirehalsadat Mousavi
  • Haiyan Xie
  • Zhiyuan Xie
  • Mikkel Brydegaard
  • Johan Axelsson
  • Stefan Andersson-Engels
Publishing year: 2013
Language: English
Pages: 90320-90320
Publication/Series: Biophotonics—Riga 2013 (Proceedings of SPIE)
Volume: 9032
Document type: Conference paper
Publisher: SPIE

Abstract english

Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies on skin lesions.


  • Atom and Molecular Physics and Optics


1st International Conference on Biophotonics-Riga
  • ISSN: 1996-756X
  • ISSN: 0277-786X
Mikkel Brygdegaard
E-mail: mikkel [dot] brydegaard [at] forbrf [dot] lth [dot] se

Associate senior lecturer

Combustion Physics

+46 46 222 76 57



Centre for Animal Movement Research
Evolutionary Ecology, Department of Biology
Ecology building S-223 62 Lund Sweden